The Prostate Cancer Clinical Trials Consortium today presented the Prostate Cancer Working Group 4 (PCWG4) clinical trials guidelines at the 2026 American Society for Clinical Oncology Genitourinary Cancers Symposium (ASCO GU), February 26 - 28, 2026. Building on the widely adopted PCWG3 framework, PCWG4 provides updated standards for enrolling patients, measuring outcomes, and interpreting results in prostate cancer clinical trials.